张志友医生, MD, PhD
创始人 / 医务主任
关于张志友医生
张志友医生是童安儿科 (Kidswell Pediatrics) 的创始人及医务主任，从医 22 年。先后于 Richmond University Medical Center 完成儿科住院医师培训，并在美国国立卫生研究院 (NIH / NICHD) 完成为期一年的儿童内分泌专科进修，现任纽约大学格罗斯曼医学院 (NYU Grossman School of Medicine) 儿科系临床讲师。在 Science、Cell、Diabetes、Gastroenterology 等国际医学期刊发表同行评审论文 24 篇。 张医生在儿童自闭症谱系障碍 (Autism Spectrum Disorder) 的评估与诊疗方面经验丰富，同时擅长儿童内分泌、生长发育等领域。家长们因儿童发育筛查、第二意见诊断、专科转诊协调，以及张医生自 2010 年以来一贯的全面儿科服务而前来就诊。 张医生在童安儿科三家诊所均亲自坐诊，并持续为整个团队制定诊疗标准。
代表性发表论文
24 篇同行评审论文另有 8 场受邀学术演讲，以及在美国糖尿病协会 (ADA)、美国心脏协会 (AHA) 等学术会议上发表的 18 篇会议摘要。
- 重点研究Zhang Z, Zhang W, Jung DY, Ko HJ, Lee Y, Friedline R, Lee E, Jun J, Ma Z, Kim F, Tsitsilianos N, Chapman K, Morrison A, Cooper MP, Miller BA, Kim JK.TRPM2 Ca2+-Channel Regulates Energy Balance and Glucose Metabolism.Am J Physiol Endocrinol Metab.2012;302(7):E807-16.PMID: 22275755 (在新标签页打开)
用大白话讲: Identified a cellular calcium channel that controls how the body burns energy and processes sugar — research with implications for understanding childhood obesity and the development of type 2 diabetes.
- 重点研究Figler RA, Wang G, Srinivasan S, Jung DY, Zhang Z, Pankow JS, Ravid K, Fredholm B, Hedrick CC, Rich SS, Kim JK, LaNoue KF, Linden J.Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans.Diabetes.2011;60(2):669-79.PMID: 21270276 (在新标签页打开)
用大白话讲: Showed that a specific cellular receptor and chronic inflammation are mechanistically linked to insulin resistance in both mice and humans — advancing our understanding of how type 2 diabetes develops at the cellular level.
- 重点研究Xu J, Lloyd DJ, Hale C, Stanislaus S, Chen M, Sivits G, Vonderfecht S, Hecht R, Li YS, Lindberg RA, Chen JL, Jung DY, Zhang Z, Ko HJ, Kim JK, Véniant MM.Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice.Diabetes.2009;58(1):250-9.
用大白话讲: Showed that the hormone FGF21 reverses fatty liver, raises metabolic rate, and restores insulin sensitivity in obese mice — a foundational study behind FGF21-targeted therapies now being developed for obesity and non-alcoholic fatty liver disease.
- 重点研究Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, Barrett T, Kim JK, Davis RJ.A stress signaling pathway in adipose tissue regulates hepatic insulin resistance.Science.2008;322(5907):1539-43.
用大白话讲: Published in Science — one of the world's top scientific journals. Identified how stress signals from fat tissue cause the liver to become insulin resistant, a foundational mechanistic discovery in the biology of type 2 diabetes.
- 重点研究Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G.Endocrine Regulation of Energy Metabolism by the Skeleton.Cell.2007;130(3):456-469.
用大白话讲: Published in Cell — a landmark study showing that bone is more than structural: the skeleton acts as an endocrine organ, sending signals (via osteocalcin) that control sugar metabolism, insulin response, and body weight. Reframed how we understand the connection between bone health and metabolic health.